Early life[ edit ] Khan was born in     or   in Bhopal. His father, Abdul Ghafoor, was an alumnus of Nagpur University and an academic who served in the Indian Education ministry then permanently settled the family in Bhopal State after he retired in Science Collegehe enrolled at Karachi University in to study physics.
T cell-depleted hla-haploidentical stem cell transplantation in thalassemia young patients. Haploidentical BMT has been explored as an option for treating patients with leukemia who lack an HLA-identical sibling or parent donor. Feto-maternal microchimerism suggests immunological tolerance between mother and fetus.
The best results are with very young children. It is protocol 30,developed by Dr. What is the payment mode? All money should be paid in one payment or in installments?
Payments are not to be done all together. Outpatient for the first 60 days they can do day to day billing. And inpatient week or two weeks at a time. Can we do BMT with parent as donor even in case of mismatch? Yes,because the mother and the father are often mismatch with the patient,and they can be used as donor in the Haploidentical BMT.
Yes,the child will be a thalassemia minor carrier,with an haemoglobin level around My daughter has Thal Major.
My daughter is beta thalassemia major,we want to go for Haploidentical BMT. Can we proceed for Haploidentical BMT? This test is not very important,and you can go for the Haploidentical BMT,but you first must do the pre transplant investigations and evaluation for the recipient child and the donor.
Are there risks for the mother who is the bone marrow donor? A central venous line is a sterile tube that is inserted into one of the larger veins —the femoral vein,internal jugular vein or subclavian vein.
The risk of serious complications from use of a central line is small. A central line will be placed only with the consent of the donor after he has received information about the possible risks.
Therefore,there are some data available about the long-term safety. We began using grow to aid in transplants in the s.
Since then,no donors also from from the international registry have reported any long-term complications from grow factor injections. Will you give any medicine to the mother before taking out her bone marrow?
There are no medicines for the mother. Only growth factor days before the BMT. After haplo BMT for how much time immunosuppression is required?
Usually we are using cyclosporin and steroids at least for one year,depending from complication like GVHD. After haplo BMT,when the vaccination can be done? The child will be observed by doctors for 1 year after the BMT,and within 1 year the vaccination can start. Our doctor says that we can do half matching with either father or mother,so haploidentical matching.
The first choice between father and mother is the mother;the reason is the intent to minimize the risk of severe GVHD,an immunological reaction,and it is based on the hypothesis of the immunological tolerance established during pregnancy between fetus and mother.
What is the percentage of required match of the mother? Can BMT be possible?
It is OK,the different blood group is not a problem. During the procedure of the mother do you require test to check how much bone marrow is matching? Or how you evaluate that the mother bone marrow is sufficiently matched to treat to the child?
We know in advance all we need. When the chemotherapy is given to the patient to remove his own existing bone marrow is this very painful? No,it is not very painful. We can control the side effects of chemotherapy using drugs.The 11th Annual Conference Academy for Sickle Cell and Thalassaemia Conference (ASCAT) is the essential event for all health care professionals who wish to learn more about the diagnosis and management of sickle cell disease and thalassaemia.
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